![]() Also, old people are likely to be living alone, without someone to tell them that they are doing something unusual, or to make them care about that fact. The aged have fewer pleasures than younger people do, and therefore may be more tempted by the prospect of having plastic flyswatters in five different colors. DSM-V says that hoarding sometimes begins in childhood, but that by the time the hoarders come to the attention of the authorities they tend to be old. Just as bereavement has an ordinary cause (death), so hoarding may be the product of unremarkable circumstances-notably modern medicine, which allows us to live longer. #The gray garden story manualIf you fail, the manual suggests, you may be the victim not only of grief but also of illness, which calls for treatment. Consider one: “persistent complex bereavement disorder.” That’s when you can’t get over the death of someone close to you within the period of time that the DSM considers to be appropriate: a year if you’re an adult, six months if you’re a child. In a section called “Conditions for Further Study,” the manual lists behaviors that it isn’t calling disorders yet but is asking us to think about. DSM-V has a new category, “excoriation (skin-picking) disorder,” which is where you could end up if you don’t stop picking your cuticles. For a number of years now, you haven’t had to do anything especially eye-catching to make it into the manual. ![]() The first edition was published in 1952 since then, it has undergone five substantial revisions, and, in the process, the concept of psychopathology has broadened. The document in which these guidelines are laid out is the fifth edition of the A.P.A.’s Diagnostic and Statistical Manual of Mental Disorders (2013), or DSM-V. says, are newspapers, magazines, old clothes, bags, books, mail, and paperwork, though valuable materials-indeed, cash and checks-may also be included with the junk. The items most commonly hoarded, the A.P.A. Hoarders also tend to go in for energetic collecting, often at inexpensive emporia-thrift shops, yard sales, and the like. is a persistent difficulty in discarding possessions, regardless of their actual value, to the point where the person’s accumulated goods congest living areas and impede their intended use. She died in 2010, and so she never had to find out that in 2013 the American Psychiatric Association declared her storage habits a diagnostic feature of a mental illness called “hoarding disorder,” or H.D. And here I came, year after year, throwing them away. Until that happened, she was making sure that she had plenty of things. Soon, she knew, she was going to lose everything she had, because she was going to lose her life. I was helping to keep her apartment in the kind of shape where no one could come in and say that she had to be moved to a nursing home-a possibility that she actively feared. ![]() She would stand below me, in her blue robe, her eyes sparkling with-what? Grief? Anger? Eagerness to fill the newly vacated space? I told myself that I was doing her a favor, and I was. I would get up on a stepladder, with a trash bag, and dump the containers in, one by one. Then, every year, shortly before Thanksgiving, I would fly in from New York to visit her, and the first thing we did on the morning after my arrival was clean out the polystyrene-container cupboard. ![]() I don’t know what she did with the dinners, but the containers were washed, patted dry, and carefully stacked on their designated shelves. She told me that she might use one as a desk organizer, or perhaps a sewing kit, with different kinds of buttons in the wells. But to my mother they were exotic, and attractive: gleaming and white, with little compartments, like a jewelry box. These boxes, with the flip-up lids, are common trash items of our time. What she did like, however, was the receptacles the dinners came in. Secretly, she wanted no part of the food. In her late years, my mother underwent several operations, and, for a long time, after she came home, Meals on Wheels delivered her dinner. She needed her kitchen cupboards for other purposes, such as her collection of polystyrene food containers. #The gray garden story installShe lived in Santa Barbara, in an apartment with a perfectly adequate kitchen, but in order to store her dishes she had to buy a freestanding cabinet and install it in the dining room. ![]() My mother survived to the age of ninety-three, so she had time to develop a number of habits that people now consider to be symptomatic of dementia. Little Edie Beale in Grey Gardens, the home she shared with her mother, in 1972. ![]()
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Our mission is to build high-quality dog products that enable endless adventures for you and your four-legged family. Headquartered in Rochester, NY - we're right here in the USA where we design and test all our gear. ![]() ![]() With its lawns, gardens and Hudson River views, the park is “the jewel of the neighborhood,” Mr. “We rent apartments to a lot of Yeshiva students as well.”Īnother attraction is the 67-acre Fort Tryon Park, which includes the Met Cloisters, part of the Metropolitan Museum of Art. “A lot of doctors and nurses and other medical personnel rent and buy in the neighborhood,” Mr. The neighborhood is also home to a number of medical and academic institutions, including Columbia University Irving Medical Center and branches of Yeshiva University and Boricua College. To the east, “some buildings are more mixed-use, residential and commercial,” said Adrivel Ruiz, an associate broker with Sovereign. Nearby is Hudson View Gardens, a 1924 Tudor Revival co-op that is on the National Register of Historic Places. Particularly imposing is Castle Village, a five-building co-op on 7.5 acres overlooking the Hudson. ![]() In Hudson Heights, west of Broadway, stately apartment buildings, some with Art Deco features, create a serene atmosphere. The west side “probably has the greatest concentration of co-ops, and some condos,” said Greg Healy, the owner-broker of the Sovereign Associates real estate agency. The area’s hilly terrain is connected by stairways known as “step streets.”īroadway divides west and east. While opinions differ, one commonly accepted boundary of Washington Heights extends from 155th Street on the south to Inwood and Dyckman Street on the north, and from the Hudson River on the west to the Harlem River on the east. Poelle said: Washington Heights is “continually reinventing itself.” They rent a three-bedroom, one-bathroom, 1,800-square-foot apartment for $3,200.Īs for any changes wrought by the pandemic? That doesn’t faze them, Mr. He and his wife, a literary agent, returned in 2019 with their daughters, now 6 and 9. That was the case, prepandemic, for Travis and Barbara Poelle, both 43, who left Washington Heights in 2015 for suburban Minneapolis, which they found “lacking in diversity” and “lacking in the culture you have in New York,” said Mr. Others who sold their apartments are seeking to return, he said: “They left for the suburbs and realized the suburbs weren’t for them.” “They have rented and now want to purchase.” Many current buyers “are from the neighborhood,” Mr. “Apartments were just sitting there.”īy late spring, the pendulum seemed to be swinging back. Parts of the neighborhood were “affected tremendously,” said Louis Pulice, an agent with Brown Harris Stevens and a lifelong Heights resident. The pandemic, however, has taken its toll on the neighborhood’s housing market. (She emphasized that she was speaking for herself, not for the board.) ![]() Diaz, who is also the first vice-chairman of Community Board 12, covering Washington Heights and Inwood to the north. “Washington Heights has among the highest number of rent-stabilized apartments in the city, so gentrification” - with its threat of market-rate rents - “is a huge concern,” said Ms. “I view Washington Heights as the last bastion of affordability in Manhattan,” said Katherine Diaz, a resident and a political consultant to the City Council candidate Angela Fernandez before the June primaries. In recent years, the neighborhood’s moderate rents and large apartments have broadened its appeal, creating concern among some residents that gentrification will drive out middle- and working-class households and mom-and-pop businesses. ![]() Madera, whose parents were born in the Dominican Republic, to “have my Dominican roots.” At the same time, the wide range of restaurants means that she also has “the option of a classic American burger, or Indian food, or Italian.” With its large Dominican community and Latin-flavored shops, restaurants and outdoor markets - celebrated in the new film adaptation of Lin-Manuel Miranda and Quiara Alegría Hudes’s Broadway show “In the Heights” - Washington Heights allows Ms. ![]() ![]() One might be off-put simply because it’s old and thus the style is pretty different than what we’re used to today. So…when you get down to it, what did I think? I loved it. The Court Jester (1955) - A hypnotized Danny Kaye romances Angela Lansbury. The Court Jester 1955 A hapless carnival performer assumes the role of the court jester as part of a plan against a usurper who has deposed Englands. ![]() #Danny kaye the court jester streaming moviePretty grim for such a light-hearted comedy. Watch The Court Jester 1955 Full Movie online free with subtitles 123movies A. Former carnival performer Hubert Hawkins (Danny Kaye) and maid Jean (Glynis Johns) are assigned to protect the infant royal heir from tyrannical King. They then role on their backs and with their legs, nimbly bounce the unconscious enemy soldiers up a staircase, across a castle roof and then right over the castle wall into the ocean where they all presumably drown in the murky depths. And then at the end, in one of the movie’s most surreal images, a troop of acrobatic midgets that are friends of Hubert’s enter the battle and help defeat enemy soldiers. In this swashbuckling comic farce, star Danny Kaye is kind-hearted entertainer Hawkins who disguises himself as the legendary king of jesters, Giacomo. A guy gets bloodlessly shot with an arrow at the start three other characters are comically poisoned to death in the middle, and another sympathetic character is tortured to death off-screen. 1955 ‘Knock on Wood’ Kaye Says ‘Entombment’ Over-article written by Danny about his movies and television Sept. TiVo Stream 4K, TiVo EDGE, TiVo Mini LUX, the TiVo logo, and the TiVo silhouette logo are all trademarks or registered. Glynis Johns, Basil Rathbone, Angela Lansbury. ![]() #Danny kaye the court jester streaming tvGet unlimited DVD Movies & TV Shows delivered to your door with no. Danny Kaye in a spoof of medieval England and costumed swashbucklers. 1955 Metalworker Helps Free Danny Kaye-brief article on an incident from the set of The Court Jester Feb. Rent The Court Jester (1956) starring Danny Kaye and Glynis Johns on DVD and Blu-ray. A carnival performer poses as a court jester in a plot to overthrow an evil king and restore to the throne the rightful heir, an infant with a distinguishing birthmark. The Court Jester is a family friendly movie, but it is also surprisingly gruesome. Behind the Hollywood Scene-interview with Danny on the set of The Court Jester Feb. Danny Kaye, Glynis Johns, Basil Rathbone, Angela Lansbury. ![]() ![]() For comparison, a subset of the inactive compounds was docked in the same way. Compounds that inhibited growth were taken as active, and each active compound was computationally docked with each of 296 AlphaFold2-predicted E. coli essential protein structures. To define our chemical space of interest, we performed high-throughput screens of growth inhibition against wild-type E. coli. In addition to inspiring further studies that expand on the interactions discovered in this way, these experiments could be used to benchmark the performance of our modeling platform and reveal the prediction accuracy possible with AlphaFold2-enabled molecular docking simulations. As computational docking approaches are known to predict many false positives (Adeshina et al, 2020), the predicted protein-ligand interactions could be experimentally interrogated, in part, using biochemical assays that measure enzymatic activity, with binding interactions supported by enzymatic inhibition. We hypothesized that such an approach could enrich for true protein-ligand interactions from the large, combinatorial space of all possible interactions between antibacterial compounds and essential proteins. Here, we reasoned that the recent release of the AlphaFold2 database of protein structure predictions (Jumper et al, 2021 Varadi et al, 2022) could enable reverse docking approaches that span Escherichia coli's essential proteome, allowing for the extensive prediction of binding targets of antibacterial compounds (Fig 1A). Although versatile, reverse docking requires a priori knowledge of the protein structures of interest, and its application to drug-target identification has been limited by the number and quality of target protein structures (Chen & Zhi, 2001 Kharkar et al, 2014 Lee et al, 2016). While docking has been used to enrich for potential hit compounds that bind pre-specified proteins in “one target, many compounds” approaches, the process of “reverse docking,” in which a small molecule is docked across different potential protein targets, leverages docking to discover binding partners and drug mechanisms of action (Kharkar et al, 2014 Lee et al, 2016). In molecular docking, ligand binding poses within a targeted binding site of a protein are computationally modeled using scoring functions, and poses are optimized to provide structural information and activity predictions in the form of thermodynamic binding affinities. Molecular docking, in particular, has proven versatile for identifying protein-ligand interactions and drug mechanisms of action. Various approaches to identifying molecular drug targets have been developed, including those based on biochemical assays, genetic interactions, and molecular docking (Kitchen et al, 2004 Schenone et al, 2013). SynopsisĪ major challenge in drug discovery is the identification of drug-target interactions. This work indicates that advances in modeling protein-ligand interactions, particularly using machine learning-based approaches, are needed to better harness AlphaFold2 for drug discovery. ![]() We demonstrate that rescoring of docking poses using machine learning-based approaches improves model performance, resulting in average auROCs as large as 0.63, and that ensembles of rescoring functions improve prediction accuracy and the ratio of true-positive rate to false-positive rate. We confirm extensive promiscuity, but find that the average area under the receiver operating characteristic curve (auROC) is 0.48, indicating weak model performance. ![]() We benchmark model performance by measuring enzymatic activity for 12 essential proteins treated with each antibacterial compound. Here, we combine AlphaFold2 with molecular docking simulations to predict protein-ligand interactions between 296 proteins spanning Escherichia coli's essential proteome, and 218 active antibacterial compounds and 100 inactive compounds, respectively, pointing to widespread compound and protein promiscuity. Computational docking approaches have been widely used to predict drug binding targets yet, such approaches depend on existing protein structures, and accurate structural predictions have only recently become available from AlphaFold2. Efficient identification of drug mechanisms of action remains a challenge. ![]() ![]() Have some inspirational math quotes handy to share with students going through a learning rut. Start learning Math with Brighterly Let’s start learning Math! 8 Inspirational Math Quotes ![]()
![]() ![]() Songs About Friendship #30: The Pretenders – I'll Stand By You. Songs About Friendship #29: Vitamin C – Graduation (Friends Forever).Songs About Friendship #28: Knife Party – Internet Friends.Songs About Friendship #27: The Rembrandts – I'll Be There for You.Songs About Friendship #26: Weezer – My Best Friend.Songs About Friendship #25: The Beatles – In My Life.Songs About Friendship #24: Mariah Carey – Anytime You Need A Friend.Songs About Friendship #23: Thin Lizzy – Boys Are Back In Town.Songs About Friendship #22: Martina McBride – This One's For The Girls.Songs About Friendship #21: Puff Daddy, Faith Evans & 112 – I'll Be Missing You.Songs About Friendship #20: Rihanna – Umbrella.Songs About Friendship #19: Marshmello & Anne-Marie – FRIENDS.Songs About Friendship #18: Spice Girls – Wannabe.Songs About Friendship #17: Rascal Flatts – My Wish.Songs About Friendship #16: Zedd – Stay The Night ft.Songs About Friendship #15: Queen – You're My Best Friend.Songs About Friendship #14: Taylor Swift – I'm Only Me When I'm With You.Songs About Friendship #13: The White Stripes – We're Going to Be Friends.Songs About Friendship #12: The Beatles – With a Little Help From My Friends.Songs About Friendship #11: Andrew Gold – Thank You For Being a Friend.Songs About Friendship #10: Daft Punk – One More Time.Songs About Friendship #9: Dionne Warwick and Friends – That's What Friends Are For.Songs About Friendship #8: SOFI TUKKER – Best Friend feat.Songs About Friendship #7: Bill Withers – Lean On Me.Songs About Friendship #5: Pharrell Williams – Best Friend.Songs About Friendship #4: LCD Soundsystem – All My Friends.Songs About Friendship #3: Bruno Mars – Count On Me.Songs About Friendship #2: Biz Markie – Just A Friend.Songs About Friendship #1: Randy Newman – You Got a Friend In Me.“Raindrops Keep Falling On My Head”-B.J.“After the Storm Blows Through”-Maddie & Tae.“I Made It Through The Rain”-Barry Manilow.“Waiting for the Thunder”-Blackberry Smoke. ![]()
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